Dihydroquercetin, often known as taxifolin, is a natural flavonoid with significant potential in promoting health. Extracted from sources like Siberian larch, it stands out for its antioxidant and anti-inflammatory properties.
This blog will explore the benefits, potential side effects, recommended uses, and dietary sources of dihydroquercetin, helping you understand its role in maintaining well-being.
Whether you’re looking to support cardiovascular health or enhance your daily wellness routine, dihydroquercetin may offer valuable benefits. Let’s take a closer look at how this powerful compound can be integrated into your lifestyle.
What is dihydroquercetin?
Dihydroquercetin or taxifolin, belongs to the flavonoid group of polyphenols, substances known for their potent antioxidant activities [1].
This compound is primarily extracted from the wood of the Siberian larch tree, but it is also found in smaller amounts in other plants like onions, milk thistle, and French maritime pine bark.
As a potent antioxidant, dihydroquercetin is popular because it can neutralize free radicals—unstable molecules that can damage cells contributing to aging and disease. By mitigating oxidative stress, DHQ helps protect the body’s tissues and supports overall health.
Its molecular structure allows it to effectively scavenge these damaging particles, enhancing its status as a vital component in supplements aimed at boosting antioxidant defenses.
Beyond its antioxidant capacity, DHQ influences several biological pathways, contributing to its anti-inflammatory and cardioprotective effects.
Research suggests it may enhance blood flow and reduce inflammation, making it a valuable ally against chronic diseases often driven by inflammatory processes [2].
The compound’s versatility extends to its use in various health products, ranging from dietary supplements to skin care formulations. In these, it helps protect the skin from oxidative damage and maintain its elasticity and tone.
What are the health benefits of dihydroquercetin?
Dihydroquercetin offers several health benefits, largely due to its potent antioxidant and anti-inflammatory properties. Here’s a closer look at how it may support your well-being:
1. Antioxidant powerhouse
Dihydroquercetin is highly effective in neutralizing free radicals, protecting cells from oxidative damage. This action helps prevent the breakdown of healthy cells, which is crucial for maintaining overall health and slowing down the aging process.
Its antioxidant capability also supports the immune system, strengthening the body’s ability to fight infections and recover from illness.
2. Cardiovascular health
One of the most significant benefits of dihydroquercetin is its positive impact on heart health. It helps improve blood circulation and reduce oxidative stress in the blood vessels, thereby aiding in maintaining healthy blood pressure levels and supporting overall cardiovascular function.
Some studies also suggest that it may reduce heart disease risks by lowering cholesterol levels [3].
3. Anti-inflammatory effects
Chronic inflammation contributes to various diseases, like arthritis, diabetes [4], and heart disease. Dihydroquercetin’s anti-inflammatory properties help diminish inflammation in the body, which could relieve symptoms of these conditions.
It prevents the formation of inflammatory cytokines, which are molecules that stimulate inflammation, granting relief from pain and swelling.
4. Skin health
Dihydroquercetin’s antioxidant properties protect the skin from environmental damage by neutralizing free radicals and promoting collagen production, leading to healthier, more resilient skin and preventing wrinkles and other signs of aging.
What is dihydroquercetin used for?
Dihydroquercetin is a popular ingredient in various health and wellness products. Here are some of the most common uses of this potent flavonoid:
1. Dietary supplements
Dihydroquercetin is widely used in dietary supplements aimed at enhancing overall health. These supplements often target specific health concerns like boosting the immune system, supporting cardiovascular health, and providing anti-aging effects due to its antioxidant properties.
It’s typically available in capsule or tablet form, making it easy to incorporate into daily health routines.
2. Therapeutic applications
In the medical field, dihydroquercetin is explored for its therapeutic potential in managing conditions like diabetes, heart disease, and chronic inflammation.
Its ability to modulate biological processes that underlie these conditions makes it a subject of interest for its potential inclusion in treatment protocols.
3. Cosmetic products
The antioxidant properties of dihydroquercetin are also harnessed in the cosmetic industry [5]. It is incorporated into skin care products like serums, creams, and lotions.
Its role in protecting the skin from oxidative stress helps prevent signs of aging like wrinkles and fine lines, while promoting a more vibrant, youthful complexion.
4. Food preservation
Dihydroquercetin is occasionally used as a natural preservative in food products due to its antioxidant properties [6]. It prevents perishable items from oxidation, which can cause spoilage, thereby prolonging their shelf life.
Is dihydroquercetin the same as quercetin?
Dihydroquercetin and quercetin are both flavonoids, natural compounds known for their potent health benefits, including antioxidant and anti-inflammatory effects.
However, despite their similarities, these two substances are not the same and possess distinct chemical structures and benefits.
Below is a table highlighting the key differences between dihydroquercetin and quercetin:
| Aspect | Dihydroquercetin | Quercetin |
|---|---|---|
| Chemical structure | Has an additional hydrogen atom which reduces double bonds. | Contains more double bonds, affecting its antioxidant power. |
| Solubility | More soluble in water, enhancing its absorption. | Less water soluble, potentially affecting bioavailability. |
| Antioxidant strength | Generally considered a stronger antioxidant. | Very effective, but slightly less potent than DHQ. |
| Anti-inflammatory | Potent anti-inflammatory properties. | Also reduces inflammation, widely studied for this effect. |
| Common sources | Mainly extracted from Siberian larch and other conifers. | Found in a broader range of foods like onions and apples. |
| Therapeutic use | Often used in cardiovascular and skin health products. | Broadly used in supplements for a variety of health issues. |
This comparison indicates that while both dihydroquercetin and quercetin are beneficial, their differences could influence which one might be preferable depending on the specific health needs and outcomes desired.
Dihydroquercetin’s enhanced solubility and strong antioxidant capacity make it particularly useful for specific therapeutic applications and as an ingredient in supplements and skincare products.
What foods are high in dihydroquercetin?
While dihydroquercetin (DHQ) is not as widely distributed in the food supply as some other flavonoids, there are still several natural sources where it can be found. Enhancing your diet with these foods can help you leverage the health benefits of DHQ [7]:
- Onions – Particularly the outer layers of onions are rich in DHQ, making them a convenient source to incorporate into daily meals.
- Grapes – The skins of grapes contain notable amounts of this flavonoid, which also contributes to the health benefits of wines, especially red wine.
- Apples – Apples, especially the skin, have a modest amount of DHQ, promoting cardiovascular health and providing antioxidant protection.
- Olive oil – High-quality olive oil is another source of DHQ, adding a heart-healthy option to the diet that supports overall wellness.
- French maritime pine bark – This is not a typical dietary food but is a rich source of DHQ and is often extracted for use in supplements.
Does dihydroquercetin have any side effects?
Dihydroquercetin (DHQ) is generally considered safe for most people when taken in recommended dosages.
However, like any supplement, you should be aware of potential side effects and safety considerations.
Common side effects
For most users, DHQ is well-tolerated, with few reported side effects. If side effects are experienced, they are typically mild and might involve gastrointestinal issues like nausea, bloating, or diarrhea [8]. Taking DHQ with food can often help reduce these symptoms.
Allergic reactions
While uncommon, some people might develop allergic responses to DHQ. Indications may include itchiness, hives, or inflammation. If you notice any symptoms of an allergic reaction, discontinue use right away and seek advice from a medical professional.
Interactions with medications
DHQ may interact with certain medications [9]. If you’re taking any prescription medications, consult your doctor before starting DHQ to avoid potential interactions.
Pregnancy and breastfeeding
There is limited research on the safety of DHQ during pregnancy and breastfeeding. Therefore, pregnant or breastfeeding women are recommended to avoid using DHQ supplements unless advised otherwise by their doctor.
Long-term safety
While short-term use of DHQ appears safe, there is limited data on its long-term effects.
As with any supplement, it’s prudent to use DHQ under the guidance of a healthcare provider, especially if you plan to use it for an extended period.
How much dihydroquercetin should you take?
Determining the appropriate dosage of dihydroquercetin (DHQ) depends on the intended health benefit and individual factors like age, health status, and dietary habits.
While research on DHQ is still evolving, general guidelines can help ensure safe and effective use.
General dosage recommendations
For most adults, a daily dose of 25-100 mg of dihydroquercetin is commonly recommended when taken as a dietary supplement [10].
This dosage is considered sufficient to provide antioxidant protection and support cardiovascular health.
For specific conditions or therapeutic uses, higher doses may be suggested, but it’s important to consult a healthcare provider before exceeding 200 mg per day.
Timing and administration
Dihydroquercetin supplements are best taken with meals to enhance absorption and minimize any potential gastrointestinal discomfort.
Since DHQ is water-soluble, it is absorbed more efficiently when taken with water or a water-based beverage.
Combination with other supplements
DHQ is often included in formulations with other antioxidants like vitamin C or quercetin to create a synergistic effect, amplifying its benefits.
However, when combining supplements, it’s essential to monitor total intake to avoid excessive dosages.
Safety considerations
Individuals with specific medical conditions, pregnant or breastfeeding women, and individuals taking medications should seek advice from a medical professional before beginning DHQ supplementation, as previously discussed.
Monitoring for any adverse reactions, like gastrointestinal upset or allergic reactions, is also advisable.
Closing thoughts
Dihydroquercetin (DHQ) provides many health benefits, because of its potent antioxidant and anti-inflammatory properties. This flavonoid enhances cardiovascular health, mitigates inflammation, and offers protective effects for the skin.
It is generally safe at recommended doses, but be aware of potential side effects. Consult a healthcare professional before starting any new supplement, especially if you have existing health conditions or are on medications.
Adding DHQ through diet or supplements could significantly bolster your wellness routine, promoting overall health and aiding in disease prevention.
FAQs
Is dihydroquercetin safe?
Dihydroquercetin (DHQ) is generally safe when used within recommended doses. It may cause mild gastrointestinal discomfort in some individuals.
What is DHQ supplement?
DHQ supplement contains dihydroquercetin, a flavonoid known for its antioxidant and anti-inflammatory benefits, commonly used to support cardiovascular and overall health.
What is the bioavailability of taxifolin?
The bioavailability of taxifolin, another name for dihydroquercetin, is relatively good due to its water solubility, enhancing its absorption in the body.
Is taxifolin the same as quercetin?
No, taxifolin and quercetin are different compounds; taxifolin has a simpler chemical structure which may affect its antioxidant strength compared to quercetin.
[1] ECronicon. Dihydroquercetin: A Novel Potent Flavonoid Antioxidant as an Adjuvant for Effective Cancer Treatment
[2] MDPI International Journal of Molecular Sciences. Taxifolin Reduces Blood Pressure via Improvement of Vascular Function and Mitigating the Vascular Inflammatory Response in Spontaneously Hypertensive Rats
[3] MDPI Nutrients. Dihydroquercetin Supplementation Improved Hepatic Lipid Dysmetabolism Mediated by Gut Microbiota in High-Fat Diet (HFD)-Fed Mice
[4] MDPI Nutrients. Taxifolin Suppresses Inflammatory Responses of High-Glucose-Stimulated Mouse Microglia by Attenuating the TXNIP–NLRP3 Axis
[5] MDPI Antioxidants. Taxifolin as a Promising Ingredient of Cosmetics for Adult Skin
[6] Wiley Online Library. Biological activities of dihydroquercetin and its effect on the oxidative stability of butter oil
[7] MDPI Molecules. Research Progress of Dihydroquercetin in the Treatment of Skin Diseases
[8] ScienceDirect. Taxifolin
[9] PubChem. Taxifolin
[10] Springer Link. Bioavailability and Safety of Dihydroquercetin (Review)
