New longevity shot offers targeted aging support for women


Happy Aging debuts NAD+ longevity shot aimed at boosting women’s cellular health, supporting wellness and slowing biological aging.

Happy Aging has introduced its NAD+ Longevity Shot alongside a biological age testing service, developed with TruDiagnostic. Founded by entrepreneur Martha Graeff and Internal Medicine Physician Dr Daniel Yadegar, the brand has created an ingestible product that combines advanced liposomal technology with high-potency ingredients intended to support cellular health and slow biological aging.

The Longevity Shot is aimed specifically at women’s aging-related health needs, and its ingredient profile includes elements like resveratrol, which is noted for antioxidant capabilities that support cellular detoxification, and nicotinamide riboside, which boosts cellular energy. The product also has a focus on skin health, including blood orange extract and spinach leaf powder which help to fortify skin through natural detoxification processes, and ceramides to help maintain skin elasticity by strengthening the skin’s barrier.

Longevity.Technology: With increasing demand in the longevity supplements industry, a noticeable shift has emerged from generalized supplements toward products tailored to target specific aging areas – such as muscle health, cognitive function and skin integrity – or particular demographics, like women in mid-life. This trend aligns with developments in biological testing that offer insights into an individual’s rate of aging and biological age; testing services, such as those provided by TruDiagnostic, allow users to measure biological markers and identify ways to influence the pace of aging through targeted wellness approaches. For consumers, these products and tests represent an expansion of agency in health, shifting focus from the inevitability of age to the manageability of its effects.

Happy Aging’s entry into the wellness market with the NAD+ Longevity Shot represents a science-forward approach that resonates with consumers increasingly interested in actionable longevity strategies; alongside its testing and age-analysis services, the brand’s collaboration with TruDiagnostic delivers a method for consumers to monitor their aging processes and adjust their wellness routines accordingly. Available directly to consumers, this range aims to offer accessible, holistic solutions for aging that prioritize health and vitality at a cellular level. To find out more about these developments, we sat down with Happy Aging cofounder Dr Daniel Yadegar.

Happy Aging cofounders Dr Daniel Yadegar and Martha Graeff

The longevity supplements market is a crowded space, and new products often need to bring something unique to the healthy aging table to be noticed. Yadegar explains that Happy Aging identified a significant gap in products that scientifically address the unique aging concerns of women. “The Longevity Shot sets a new standard by combining cutting-edge science with holistic wellness, focusing on cellular health and longevity,” he told us. “Our formulation is designed to slow down biological aging, enhance skin elasticity, and boost energy levels, offering women a comprehensive solution to age beautifully and confidently.

Determining the formulation, of course, was a key part of the design process, and Yadegar says it involved a “meticulous selection of ingredients known for their longevity benefits.”

“We chose Resveratrol and Nicotinamide Riboside (NR) for their proven roles in supporting cellular health and DNA repair,” he explains, adding that these ingredients work synergistically to enhance mitochondrial function and promote skin health. “Our advanced liposomal delivery ensures maximum bioavailability, making sure each nutrient reaches its target effectively, thereby addressing women’s unique health and aging needs.”

NAD+ is a vital coenzyme for cellular energy and repair processes, but its levels drop as we age, meaning that cells become less efficient at energy production and repair, which contributes to the aging process. Supplementing with a precursor such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), molecules that serve as building blocks for NAD+, can help to boost NAD+ levels and protect against age-related decline in cellular function and overall health. This supplementation has been associated with potential benefits such as improved metabolic health, enhanced cognitive function and better cellular resilience.

“We opted for Nicotinamide Riboside (NR) over NMN due to its superior bioavailability and well-documented efficacy in replenishing NAD+ levels,” says Yadegar. “Its ability to efficiently boost NAD+ levels makes it an ideal choice for supporting healthy aging and vitality in women.”

Off-the-shelf supplements, even those designed to target a specific area of aging or group of people, often take a broad approach, but by combining them with biological age testing, consumers can obtain the personalized insights needed to tailor their health and wellness strategies effectively.

For this reason, Happy Aging is collaborating with TruDiagnostic to offer advanced biological age testing, and it is a decision Yadegar says is driven by the pursuit of more targeted, evidence-based wellness solution

“The Longevity Shot and the TruDiagnostic Biological Age Test are closely connected, offering a synergistic approach to wellness,” he explains. “One of the key benefits of the Longevity Shot is its ability to reduce the pace of aging by maintaining elevated NAD+ levels. The TruDiagnostic Biological Age Test measures this pace of aging, providing personalized insights into how quickly your body is aging.”

Yadegar explains that by using the test, women can assess the impact of incorporating the Longevity Shot into their healthy routine, alongside other lifestyle changes Happy Aging recommends through its educational resources, such as its free e-book, The Art of Aging Well. “This combination allows women to create a balanced and informed wellness strategy, tailored to their unique needs and goals.”

As women transition through perimenopause and menopause, their health and wellness needs evolve, and Yadegar says that the Longevity Shot is crafted to support women through the physiological changes of perimenopause and menopause by enhancing cellular health and vitality.

“Its ingredients, such as Resveratrol and NR, help maintain energy levels, support hormonal balance, and improve skin elasticity, addressing common concerns during these stages,” he explains. “By promoting a healthier pace of aging and providing antioxidant protection, the Longevity Shot offers women a supportive tool for maintaining overall well-being and confidence during these transitions.”

Photographs courtesy of Happy Aging



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