September event brings leading researchers and clinicians together to explore the longevity-linked protein and its emerging therapeutic role.
The science of aging is moving rapidly from theory to translation – and this September, those looking to be at the forefront of that shift should plan to be in Irvine, California. Registration is now open for the world’s first dedicated Klotho Conference, a two-day event bringing together leading researchers, clinicians and biotech innovators to explore one of the most promising longevity proteins in human biology. Discovered in 1997 and now firmly linked to healthier aging, Klotho is gaining momentum as both a therapeutic target and a clinical tool. From cognition to regeneration, the focus is now on practical strategies to increase circulating Klotho in humans – and this event marks the first time the field’s key players will gather under one roof to share data, protocols and outcomes.
The Klotho Conference, held at the UCI Cove Beall Applied Innovation Center from 15–16 September, will explore the role of the protein in cognitive resilience, muscle regeneration, immune health and biological aging. It is being organized by Lionheart Health, Inc, a company which, through its clinical and wellness arms, has developed a range of Klotho-linked interventions. The event will culminate in a three-day wellness retreat at The Montage in Laguna Beach, offering what its organizers describe as a holistic immersion in longevity-focused living.
Longevity.Technology: The emergence of Klotho as a central player in the geroscience landscape is not new – researchers have been quietly tracing its protective effects for over two decades – but what’s shifting now is momentum: not just in the lab, but in the clinic, the wellness sector and, increasingly, the commercial arena. There is something refreshingly unapologetic about the way Lionheart is weaving translational science into a high-touch wellness model; one might bristle at first glance – state-of-the-art biotech meets lifestyle retreat – but there is intellectual seriousness here too, not least in the lineup of speakers set to gather under the banner of the first dedicated Klotho conference. This convergence of cellular rejuvenation, gene therapies and personalized protocols reflects something deeper: a growing impatience with the passive aging narrative and a willingness to treat decline as a solvable problem, rather than an inevitability. If Klotho truly holds the keys to recalibrating the aging trajectory – and the data are increasingly hard to ignore – then integrating it into both scientific dialogue and consumer access may be less a question of if, and more one of how fast.
Scientific depth and clinical breadth
The conference agenda is structured to reflect Klotho’s multifaceted profile, with presentations ranging from mechanistic brain research and musculoskeletal regeneration to gene therapies, immune function and aesthetic medicine. The event features a keynote from Dr Makoto Kuro-o – who first identified Klotho nearly 30 years ago – as well as panels on neurobiology, cardiovascular applications and cancer-related research as well as cocktail receptions on both days.
Other speakers include:
- Dr Mona Ezzat-Velinov and Dr Jorge Genovese in a muscle health panel.
- Dr Patrick Sewell on developments in gene therapy and clinical translation.
- Dr Carmela Abraham in a featured address.
- Dr Dena Dubal in a Klotho brain research panel.
- Petr Šrámek on human case studies with Klotho therapy.
- Dr Doris Taylor on Klotho and regenerative medicine.
And you can check out the full speaker list HERE.
Howard Leonhardt, Executive Chairman and CEO of Lionheart Health, will also speak at the event discussing how Klotho features in XPRIZE Healthspan. “We’ve spent years building the science, refining protocols and listening to what both patients and practitioners need,” he told Longevity.Technology. “Now, for the first time, the leading minds in Klotho research and clinical application will be in one place – and I believe it’s going to move the field forward in a very real way.” You can watch Leonhardt discussing the conference HERE.
From molecule to model of care
Klotho, often described as a “longevity protein,” has been shown to influence cellular pathways related to oxidative stress, mitochondrial efficiency and inflammatory balance. Its decline is associated with a variety of age-related conditions – including cognitive impairment, muscle wasting, kidney dysfunction and immune senescence – and its elevation in animal models has demonstrated improvements in regeneration, function and lifespan. Human data remain early-stage but promising; low Klotho levels have been linked to increased all-cause mortality, while higher levels correlate with better cognitive and physical performance in aging populations.
Lionheart Health’s own approach reflects a blend of diagnostics and intervention, combining blood biomarker analysis and genetic screening with personalized treatment plans. Its Newport Beach and Manhattan clinics offer therapies that range from bioelectric stimulation and EMS suits and tailored supplement plans, all framed within a broader goal of enhancing healthspan rather than merely extending lifespan. Lionheart Health also refers access to Klotho gene and cell therapies in select licensed, certified and trained OUS clinics and has a patent on Klotho expressing stem cells.
A model for longevity licensing
Beyond its clinics, Lionheart has launched a licensing program that enables other providers to deliver its suite of therapies and technologies – a strategy designed to expand access while maintaining clinical oversight. Participating clinics gain access to patented technologies, treatment protocols and wellness products, effectively joining a network that operates at the intersection of regenerative medicine, preventive health and personalized longevity.
This expansion model is both pragmatic and reflective of a broader trend in the field: the move away from one-size-fits-all antiaging interventions toward systems that integrate data, clinical judgment and patient preference. The Klotho Conference, in this light, becomes not just a scientific gathering but a platform for building community and commercial alignment across the longevity space.
A catalytic moment
As longevity science evolves, proteins like Klotho are no longer viewed as isolated biological curiosities but as potential levers – subtle, multifaceted, and highly individual – that may help rebalance the physiology of aging. For those wishing to engage directly with the science and its clinical translation, registration for the Klotho Conference is now open; attendees will also benefit from exclusive access to the Lionheart Wellness Retreat and a suite of event-only offers, including 20% discounts on Klotho therapies, diagnostic tests and participation in the Lionheart Klotho Wellness Program.
